ABSTRACT
For several years it was believed that angiotensin II (Ang II) alone mediated the effects of the renin-angiotensin system. However, it has been observed that other peptides of this system, such as angiotensin-(1-7) (Ang-(1-7)), present biological activity. The effect of Ang II and Ang-(1-7) on renal sodium excretion has been associated, at least in part, with modulation of proximal tubule sodium reabsorption. In the present review, we discuss the evidence for the involvement of Na+-ATPase, called the second sodium pump, as a target for the actions of these compounds in the regulation of proximal tubule sodium reabsorption
Subject(s)
Animals , Angiotensin II/physiology , Angiotensin I/physiology , Extracellular Space/enzymology , Kidney Tubules, Proximal/enzymology , Sodium-Potassium-Exchanging ATPase/metabolism , Sodium/urine , Extracellular Space/physiology , Receptors, Angiotensin/physiologyABSTRACT
Descrevemos o isolamento do C. diphtheriae em uma regiäo endêmica da leishmaniose cutâneo-mucosa por Leishmania braziliensis braziliensis. Materiais das lesöes cutâneas foram obtidos de dezesseis pacientes. Nove deles foram portadores do bacilo (56%). Os microrganismos suspeitos foram identificados pelos testes de fluorescência sob luz ultravioleta, teste de virulência "in vitro" (por imunodifusäo radial simples), pesquisa da enzima pirazina-carboxilamidase (Pyz) e por imunofluorescência direta e indireta